Open_basedir proper settings in php.ini System check fails

Thanks for reading & I appreciate all response:
Windows Server 2012 R2 ESXi-VM
Matomo/PIWIK 4.4.1
PHP 8.0.9
MySQL 8.0.26
2 core
I have been wrestling with the open_basedir configurations in the php.ini file and found some issues which I assume it is my lack of understanding how the configuration is really used. I have looked over the php documentations here:
and that wasn’t too clear for my issue. Currently the system runs real fast without enabling open_basedir, but as soon as I enable it the system slows down to a snails pace. Also, I found that once enabled the system check fails. This is odd for me, because if open_basedir is not enabled the system check happens fast and shows nothing is wrong. Below is the entry I have added that causes this issue:
open_basedir = E:\inetpub\wwwroot\

Am I missing something? I have seen reference to adding multiple entries in the open_basedir, but could find no reference to a standard configuration.
Thanks again

I would like to do the same thing. Can you please help me here?