IIS Installation Settings Best Practices

I am looking for the Best practices for running PIWIK on an IIS server. Using the Microsoft “Web Platform Installer” the majority of the work was done for me. I notice that in the Application Pools of IIS the PIWIK App is showing with NO .NET CLR Version identified and is using Classic Managed Pipeline Mode.

Are there any benefits to changing the mode to v4.0 and integrated? Is this a bad option?

Server: 2012 R2
PIWIK: 2.16.0
MySQL: 5.1
PHP: 7.0.0
Python: 2.7.11

We have created a program to import multiple sites by using their respective log files.This process may be suitable as a plugin.